shs4b 2zyet 2h9be 86ha7 aify8 9a5de dynzk rh9ar t33s4 7rzdr se434 334t5 7znif 44s44 7hrz3 fse5z zi4ka sb3hy tde8r n2e6r 742kn UCSC is deciding to go back in person, so other UCs will probably do the same |

UCSC is deciding to go back in person, so other UCs will probably do the same

2022.01.20 17:45 pokemonareugly UCSC is deciding to go back in person, so other UCs will probably do the same

UCSC is deciding to go back in person, so other UCs will probably do the same submitted by pokemonareugly to UCSD [link] [comments]


2022.01.20 17:45 Far-Chef-982 (FREE) Westside Gunn x Conway The Machine X Griselda Type Beat "Bullet Club", any kind of support is welcome ❤️🙏

(FREE) Westside Gunn x Conway The Machine X Griselda Type Beat submitted by Far-Chef-982 to YoutubeProducers [link] [comments]


2022.01.20 17:45 Icy-Celebration3662 DRAFT STARTS AT 7:00 est https://discord.gg/AYrHSwJ4 League name: Pushing Madden Pw: Gunna

DRAFT STARTS AT 7:00 est https://discord.gg/AYrHSwJ4 League name: Pushing Madden Pw: Gunna
submitted by Icy-Celebration3662 to Madden22Franchise [link] [comments]


2022.01.20 17:45 Mr_LoveCrafter I'm stuck.

Nothing I do seems to work or help out. I try to be the reed in the wind, go with the flow, all that. I keep open and hoping for change that doesn't come. What can I do to keep myself sane in the times I find are the most tiring?
submitted by Mr_LoveCrafter to Shamanism [link] [comments]


2022.01.20 17:45 martialarcher What kind of spider is this? Found in Washington state.

What kind of spider is this? Found in Washington state. submitted by martialarcher to spiderbro [link] [comments]


2022.01.20 17:45 Tariq_7 Brent Central Mosque Launches "Breathe Easy" Support Group ... (for asthma & lung conditions)

Brent Central Mosque Launches submitted by Tariq_7 to BritishMuslims [link] [comments]


2022.01.20 17:45 kt80111 Any voice over artists in the UK?

As an intro - I am disabled and looking to start working from home. I had seen good education before I got I'll (to post grad level) and I have been told many times that I have a good reading voice, but from the articles I've read it sounds as though there needs to be a lot of preparation before you can get started, e.g. coaching, setting up a home studio, software, building a portfolio, etc.
My questions are: How did you get started? Do you have any key tips? Suggestions for coaching? Building a portfolio up? Applying for work? Pros and cons? Any advice or experience would be very gratefully received! TIA x
submitted by kt80111 to AskUK [link] [comments]


2022.01.20 17:45 HykaliaN What happens when you touch Dwayne Johnson’s butt?

You hit rock bottom.
I’m so sorry…
submitted by HykaliaN to jakertown [link] [comments]


2022.01.20 17:45 FreddyFrogFrightener Are there any plasma donation centres locally? Looking to donate by the only ones I can see are 2-3 hours away

submitted by FreddyFrogFrightener to Hull [link] [comments]


2022.01.20 17:45 anonlabrat69 People who live downtown and still haven’t dug your cars out

Why are you like that? Do you always just waste space wherever you go?
The police are working on towing these cars, but there’s a very long list I’ve heard.
It’s frustrating because your car is not only taking up two parking spots, but also preventing plows from clearing out that side.
submitted by anonlabrat69 to Erie [link] [comments]


2022.01.20 17:45 Totiillas International horse camps?

Does anyone know of any horse weekends/full weeks “camps” that mainly focus on jumping? I’m just looking for a place, preferably in an english speaking country or Scandinavian country, where they offer good horses and trainers. Price doesn’t really matter.
Unfortunately my plan to go to a Swedish dressage place fell through:( I’m fully vaccinated and from a place with very few covid restrictions:) It would be really nice if people could share expieriences and links?
submitted by Totiillas to Horses [link] [comments]


2022.01.20 17:45 aleks1hoo Anyone got tips for alternate picking? [QUESTION]

I just can’t alternate pick smoothly
So, I have been practising alternate picking last days and i just can’t get is done properly and smooth, i have played few months until i read how important alternate picking is.
Well, anyone got any tips?
submitted by aleks1hoo to Guitar [link] [comments]


2022.01.20 17:45 Longjumping_Exam_981 My brother just won the award of the strongest positive test of the year 🏆

My brother just won the award of the strongest positive test of the year 🏆 submitted by Longjumping_Exam_981 to medical [link] [comments]


2022.01.20 17:45 dragon8power Trading areo oh

submitted by dragon8power to YourBizzareAdventure [link] [comments]


2022.01.20 17:45 Cruijff_Neeskens Streak 11: Pauze

Hoi allemaal,
Ik heb vanavond de BOOS aflevering over seksueel misbruik bij The Voice gekeken. Ik moet morgen vroeg wakker worden en heb dus geen tijd om een tekst te schrijven voordat ik ga slapen. Ik zal morgen een lange tekst schrijven om dit goed te maken.
Bedankt voor het lezen!
submitted by Cruijff_Neeskens to WriteStreakNL [link] [comments]


2022.01.20 17:45 keryia Chris Baber Meal Pack Photos

Made them all as per the recipes except I made my own tortillas. Hubby liked all, even the avocado.
https://preview.redd.it/g037rk12nwc81.png?width=1751&format=png&auto=webp&s=749d773e3ab9e28a0e04f824468e455046db8e04
https://preview.redd.it/w1at7ji0nwc81.png?width=1751&format=png&auto=webp&s=3a81f6c0e30caaf935c0a4e3017f9984e4f0cf20
https://preview.redd.it/bxfdhfjymwc81.png?width=985&format=png&auto=webp&s=5b3f49ea49bf7c2494ad0741a8add3ad0034db5d
submitted by keryia to SortedFood [link] [comments]


2022.01.20 17:45 ImAredditor47 I’m still on the call lol

I’m still on the call lol submitted by ImAredditor47 to MinecraftMemes [link] [comments]


2022.01.20 17:45 Tenacious_Jey Mandy Rose

Mandy Rose submitted by Tenacious_Jey to WrestlingAndMMABabes [link] [comments]


2022.01.20 17:45 hodlethereum11 1 ETH = 1 ETH Always.

Unless the technology changes for the worse or something bad happens to Ethereum (not the price) then it might be time to panic.
But price fluctuations shouldn’t cause panic. 1 Ethereum is still 1 Ethereum or in my case 0.001 ETH is still 0.001 ETH.
submitted by hodlethereum11 to ethtrader [link] [comments]


2022.01.20 17:45 chrisawesomeson Mariokart 64 - Mario Raceway bass and acoustic guitar cover

Mariokart 64 - Mario Raceway bass and acoustic guitar cover submitted by chrisawesomeson to gamemusic [link] [comments]


2022.01.20 17:45 Ricosss Ketogenic diet ameliorates lipid dysregulation in type 2 diabetic mice by downregulating hepatic pescadillo 1 (Pub Date: 2022-12-01)

https://doi.org/10.1186/s10020-021-00429-6
Ketogenic diet ameliorates lipid dysregulation in type 2 diabetic mice by downregulating hepatic pescadillo 1 Abstract Background Previous reports implied a possible link between PES1 and lipid metabolism. However, the role of PES1 in regulating T2DM related lipid metabolism and the effect of ketogenic diet (KD) on PES1 have not been reported. The aim of present study is to explore the role of PES1 in effects of KD on diabetic mice and its mediated mechanism.
Methods Male C57BL/6J and KKAy mice were fed with standard diet (SD) and KD, respectively. Simultaneously, McArdle 7777 cells were treated by β-hydroxybutyric acid (β-HB), Pes1 siRNA or Pes1 overexpression plasmid, respectively. Additionally, liver-conditional knockout (CKO) of *Pes1 *in vivo was applied.
Results Hepatic PES1 expression in diabetic mice was markedly increased, which was suppressed by KD feeding with an accompanying reduction of hepatic and plasma triglycerides (TG). In mice with CKO of Pes1, the protein levels of p300, SREBP1c, FASN, SCD1, Caspase1, NLRP3 and GSDMD were dramatically downregulated in livers, and the plasma and hepatic TG, IL-1β and IL-18 were decreased as well. The similar outcomes were also observed in β-HB and Pes1 knockdown treated hepatocytes. By contrast, Pes1 overexpression in cultured hepatocytes showed that these levels were significantly enhanced, which were, however reduced under β-HB treatment. Mechanistically, we discovered that β-HB decreased CHOP binding to the Pes1 promoters, resulting in the downregulation of PES1, thereby reducing PES1 binding to p300 and Caspase1 promoters. The inhibition of p300 and Caspase1 expression elicited the dramatic suppression of acetylation of SREBP1c via its interaction with p300, and the decreased GSDMD levels. Besides, knockdown of Caspase1 also alleviated the TG levels in cultured hepatocytes.
Conclusion KD may improve lipid dysregulation in type 2 diabetic mice by downregulating hepatic PES1 expression.
------------------------------------------ Info ------------------------------------------
Open Access: True (not always correct)
Authors: * Jielin Zhou * Yao Lu * Yajing Jia * Jing Lu * Zhengxuan Jiang * Keyang Chen
Additional links: * https://molmed.biomedcentral.com/track/pdf/10.1186/s10020-021-00429-6 * https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722053 * https://www.researchsquare.com/article/rs-951448/v1.pdf?c=1641221680000
submitted by Ricosss to ketoscience [link] [comments]


2022.01.20 17:45 StupidMar0nGuy Фермерша от Yakovlev-vad

Фермерша от Yakovlev-vad submitted by StupidMar0nGuy to PikabuMLP [link] [comments]


2022.01.20 17:45 dorianrose Best French dip?

I've been craving a French dip, who does it best in your opinion?
submitted by dorianrose to grandrapids [link] [comments]


2022.01.20 17:45 Serixplayz Question for the grinders

What is your usual grinding routine? What money goal are you trying to hit (if you have one)?
submitted by Serixplayz to gtaonline [link] [comments]


2022.01.20 17:45 Sad_Permission_8505 Dating a fit girl

Where's a good place to meet and flirt with fit girls? I'm a fit guy, but train in a home gym since covid started :(
Any tips for flirting in the gym? The gym never seems like the right place to do it for me, but that could be more to do with not knowing how to do the approach at the gym.
It's not that I don't have any game at all, I just struggle at the gym. Maybe going to a fitness expo would have better results, or if I join my school's powerlifting club when we're allowed to go back on campus.
I just think it would be really cool to have somebody that understands my hobby of weightlifting/fitness.
submitted by Sad_Permission_8505 to datingadviceformen [link] [comments]


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